Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell death in the mammalian visual system during normal development: II. Superior colliculus

B L Finlay, A T Berg, D R Sengelaub

    The Journal of Comparative Neurology
    |February 1, 1982
    PubMed
    Summary

    Early hamster brain development involves significant cell loss in the superior colliculus, particularly at its margins. This cell degeneration pattern mirrors that observed in the retina during the same postnatal period.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Reflex activity of the pubococcygeus muscle is modified throughout the estrous cycle in Wistar rats.

    Neuroscience letters·2021
    Same author

    Robinson and madison have published no data on whether polyethylene glycol fusion repair prevents reinnervation accuracy in rat peripheral nerve.

    Journal of neuroscience research·2016
    Same author

    The curious ability of polyethylene glycol fusion technologies to restore lost behaviors after nerve severance.

    Journal of neuroscience research·2015
    Same author

    The epidemiology of seizure disorders in infancy and childhood: definitions and classifications.

    Handbook of clinical neurology·2013
    Same author

    Brain-derived neurotrophic factor and androgen interactions in spinal neuromuscular systems.

    Neuroscience·2012
    Same author

    Neural sensitivity to sex steroids predicts individual differences in aggression: implications for behavioural evolution.

    Proceedings. Biological sciences·2012

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Cell Biology

    Background:

    • Cell degeneration is a normal process during early development.
    • The superior colliculus plays a crucial role in visual processing.
    • Understanding cell death patterns is vital for comprehending brain development.

    Purpose of the Study:

    • To investigate the occurrence and distribution of degenerating cells in the hamster superior colliculus during early postnatal development.
    • To compare the patterns of cell degeneration in the superior colliculus with its major innervating structure, the retina.

    Main Methods:

    • Light microscopy was used to observe and quantify degenerating cells.
    • Cell degeneration rates were assessed in different layers and regions of the superior colliculus.

    Related Experiment Videos

  • Data were collected across various postnatal days.

    • Main Results:

    • Degenerating cells were observed in all layers of the superior colliculus, with higher rates at the margins of the superficial gray layer.
    • Cell death rates were consistently higher in the intermediate and deep gray layers compared to the superficial gray layer.
    • The temporal and spatial patterns of cell degeneration in the superior colliculus were similar to those in the retina.

    Conclusions:

    • Despite low observable rates, rapid debris clearance suggests substantial cell loss in the developing hamster midbrain tectum.
    • The similar degeneration patterns in the superior colliculus and retina indicate coordinated developmental processes.
    • These findings contribute to understanding neural development and plasticity.