Flexor and extensor postures in sedative drug-induced coma

Flexor and extensor postural reflexes are most commonly seen in coma after structural brain lesions, but may also occur in metabolic coma. We report 10 patients who exhibited flexor or extensor posturing as an early and transient feature of coma resulting from sedative drug ingestion. In comatose patients with normal pupillary reactivity but no ocular movements, these postural responses suggest sedative drug overdose.