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Related Experiment Videos

Reduction of hypoxic ventilatory drive by dopamine

D S Ward, J W Bellville

    Anesthesia and Analgesia
    |April 1, 1982
    PubMed
    Summary

    Low dose dopamine significantly depresses the hypoxic ventilatory response in healthy subjects. This finding highlights dopamine

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    Area of Science:

    • Physiology
    • Neuropharmacology

    Background:

    • The hypoxic ventilatory drive is crucial for maintaining oxygen homeostasis.
    • Dopamine's role in modulating respiratory responses requires precise definition.

    Purpose of the Study:

    • To investigate the precise effects of low-dose dopamine on the hypoxic ventilatory drive in healthy humans.

    Main Methods:

    • Two experimental protocols were conducted in five healthy subjects with controlled end-tidal CO2.
    • Experiments involved dopamine infusion (3 microgram/kg/min) during hypoxia and comparison of ventilatory responses with and without dopamine.

    Main Results:

    • Dopamine infusion decreased ventilation to 60% of preinfusion levels during sustained hypoxia.
    • The increase in ventilation in response to a hypoxic stimulus was significantly blunted during dopamine infusion compared to baseline.

    Conclusions:

    • Low-dose dopamine acts as a potent depressant of the hypoxic ventilatory response.
    • These findings suggest a significant interaction between dopamine and the chemoreceptor system regulating breathing during hypoxia.

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