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Reduction of hypoxic ventilatory drive by dopamine
Anesthesia and Analgesia
|April 1, 1982
Summary
Low dose dopamine significantly depresses the hypoxic ventilatory response in healthy subjects. This finding highlights dopamine
Area of Science:
- Physiology
- Neuropharmacology
Background:
- The hypoxic ventilatory drive is crucial for maintaining oxygen homeostasis.
- Dopamine's role in modulating respiratory responses requires precise definition.
Purpose of the Study:
- To investigate the precise effects of low-dose dopamine on the hypoxic ventilatory drive in healthy humans.
Main Methods:
- Two experimental protocols were conducted in five healthy subjects with controlled end-tidal CO2.
- Experiments involved dopamine infusion (3 microgram/kg/min) during hypoxia and comparison of ventilatory responses with and without dopamine.
Main Results:
- Dopamine infusion decreased ventilation to 60% of preinfusion levels during sustained hypoxia.
- The increase in ventilation in response to a hypoxic stimulus was significantly blunted during dopamine infusion compared to baseline.
Conclusions:
- Low-dose dopamine acts as a potent depressant of the hypoxic ventilatory response.
- These findings suggest a significant interaction between dopamine and the chemoreceptor system regulating breathing during hypoxia.
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