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Pulmonary function in identical twins raised apart

D Hankins, C Drage, N Zamel

    The American Review of Respiratory Disease
    |January 1, 1982
    PubMed
    Summary
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    Genetic factors significantly influence susceptibility to airway obstruction from smoking. This study of twins raised apart found that pulmonary function tests could distinguish smokers from non-smokers, highlighting genetic contributions to smoking-related respiratory issues.

    Area of Science:

    • Pulmonary Medicine
    • Twin Studies
    • Genetics

    Background:

    • The Minnesota Study of Twins Raised Apart investigates genetic and environmental influences on various traits.
    • Understanding genetic predisposition to smoking-related respiratory conditions is crucial for public health.

    Purpose of the Study:

    • To assess the role of genetic factors in determining susceptibility to airway obstruction caused by cigarette smoking.
    • To identify pulmonary function tests that can differentiate smokers from non-smokers in genetically similar individuals.

    Main Methods:

    • Studied 15 monozygotic twin pairs and one set of monozygotic triplets separated early in life.
    • Administered thirteen pulmonary function tests to each participant.
    • Analyzed pulmonary function data, comparing intratwin differences in concordant (smoking/non-smoking) and discordant twin pairs.

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    Main Results:

    • FEF25-75% and V75 statistically separated smokers from non-smokers.
    • FEV1 was most sensitive in discordant pairs for differentiating smokers.
    • Intratwin differences in pulmonary function were small in concordant pairs but large in discordant pairs.

    Conclusions:

    • Genetic factors play a significant role in determining an individual's susceptibility to airway obstruction from cigarette smoke.
    • Pulmonary function test results in twins raised apart provide evidence for genetic influence on smoking-induced respiratory damage.