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Fatal infection with echovirus 11

P J Berry, J Nagington

    Archives of Disease in Childhood
    |January 1, 1982
    PubMed

    Insights

    Echo 11 virus infections pose a significant danger to neonates, particularly those lacking maternal antibodies. This study details 24 fatal pediatric cases, highlighting distinct clinical presentations and outcomes based on age.

    Area of Science:

    • Pediatric Infectious Diseases
    • Virology
    • Neonatal Pathology

    Background:

    • Echovirus 11 (EV-B11) is a known human enterovirus.
    • Fatal infections in children are rare but can be severe.
    • Understanding EV-B11 pathogenesis is crucial for neonatal and pediatric health.

    Purpose of the Study:

    • To analyze fatal Echovirus 11 infections in children over an 11-year period.
    • To characterize clinical and pathological findings in different age groups.
    • To identify risk factors associated with severe outcomes.

    Main Methods:

    • Retrospective analysis of 24 fatal pediatric cases of Echovirus 11 infection (1968-1978).
    • Clinical data review including age at death and presenting symptoms.
    • Necropsy findings including histopathology and viral detection in tissues.

    Main Results:

    • Two distinct groups emerged: 12 neonates (5-11 days old) with disseminated intravascular coagulation and hemorrhage, and 12 older children (9 weeks-4.8 years) with varied pathologies including pneumonia and encephalitis.
    • Neonatal deaths were linked to maternal transmission, low maternal antibodies, and prematurity.
    • The role of EV-B11 in sudden deaths of older children, including 'cot deaths', remains uncertain.

    Conclusions:

    • Echovirus 11 presents a severe threat to neonates, especially those without maternal antibody protection.
    • Clinical presentation and outcomes vary significantly with age.
    • Further research is needed to elucidate EV-B11's role in sudden infant deaths.

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