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Relationship between intestinal volume secretion and oxygen uptake

D N Granger, P R Kvietys, M A Perry

    Digestive Diseases and Sciences
    |January 1, 1982
    PubMed
    Summary
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    This study reveals that intestinal secretion significantly increases oxygen uptake in the small bowel. The metabolic demands of secretion in the ileum surpass those of absorption.

    Area of Science:

    • Gastroenterology
    • Physiology
    • Metabolism

    Background:

    • Intestinal secretion involves complex physiological processes impacting gut function.
    • Understanding the metabolic cost of intestinal secretion is crucial for comprehending gut homeostasis.

    Purpose of the Study:

    • To investigate the effects of net volume secretion on intestinal blood flow, oxygen extraction, and oxygen uptake.
    • To determine the relationship between secretion rate and oxygen consumption in the feline ileum.

    Main Methods:

    • Autoperfused segments of cat ileum were used.
    • Intestinal secretion was induced using various secretagogues (glucagon, histamine, theophylline, prostaglandin E1, vasoactive intestinal peptide, cholera toxin, ricinoleic acid).
    • Net volume secretion rates were measured using a volume recovery method.

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    Main Results:

    • All tested secretagogues increased intestinal oxygen uptake.
    • Increased oxygen uptake was attributed to enhanced blood flow, oxygen extraction, or both.
    • Positive correlations between oxygen uptake and secretion rate were observed with cholera toxin, theophylline, and prostaglandin E1.

    Conclusions:

    • The metabolic work associated with intestinal secretory states is substantially higher than that of absorptive states.
    • These findings highlight the significant energy expenditure required for active intestinal secretion.