Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Long-term toxicity study quillaia extract in rats

J J Drake, K R Butterworth, I F Gaunt

    Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Interventions to reduce consumption of sugar-sweetened beverages or increase water intake: evidence from a systematic review and meta-analysis.

    Obesity reviews : an official journal of the International Association for the Study of Obesity·2017
    Same author

    Effects of vapocoolant spray on skin sterility prior to intravenous cannulation.

    The Journal of hospital infection·2015
    Same author

    Effects of urban density on carbon dioxide exchanges: Observations of dense urban, suburban and woodland areas of southern England.

    Environmental pollution (Barking, Essex : 1987)·2015
    Same author

    Temporal variability of the elemental composition in urban street dust.

    Environmental monitoring and assessment·2013
    Same author

    Sano tissue glue skin grafting.

    The Journal of the International College of Surgeons·2010
    Same author

    Use of scanning electron microscopy in the study of nephrotoxin-induced renal proximal tubular damage in vitro.

    Toxicology in vitro : an international journal published in association with BIBRA·2010

    Quillaia extract showed no carcinogenic effects in rats over a 2-year study. The highest dietary level of 3.0% was determined as the no-untoward-effect level.

    Area of Science:

    • Toxicology
    • Natural Product Research

    Background:

    • Quillaia extract is derived from the soapbark tree (Quillaja saponaria Molina).
    • Its safety profile for long-term dietary consumption requires thorough toxicological evaluation.

    Purpose of the Study:

    • To assess the chronic toxicity and carcinogenicity of quillaia extract in a rodent model.
    • To establish a no-untoward-effect level (NOEL) for dietary quillaia extract.

    Main Methods:

    • A 2-year dietary study involving 48 male and 48 female rats per group.
    • Administration of quillaia extract at dietary levels of 0%, 0.3%, 1.0%, and 3.0%.

    Main Results:

    • No adverse effects on mortality, clinical chemistry, hematology, or histopathology were observed.

    Related Experiment Videos

  • A 3% dietary level in males showed reduced body weight, kidney lesions, and organ weights, attributed to decreased food intake.
  • No evidence of carcinogenicity was found at any tested dose.

    • Conclusions:

    • Quillaia extract is not carcinogenic in rats at dietary levels up to 3.0%.
    • The no-untoward-effect level was established at 3.0% in the diet, approximately 1.5 g/kg/day.