Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal function in the term pregnant rat: a micropuncture study

S E Churchill, H H Bengele, E A Alexander

    Renal Physiology
    |January 1, 1982
    PubMed
    Summary

    Pregnancy in rats does not alter individual nephron function, but sodium retention occurs due to a failure to inhibit tubular sodium reabsorption despite expanded extracellular fluid volume.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Absence of evidence for increase in risk for autism or attention-deficit hyperactivity disorder following antidepressant exposure during pregnancy: a replication study.

    Translational psychiatry·2016
    Same author

    The foot of Homo naledi.

    Nature communications·2015
    Same author

    Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system.

    Molecular psychiatry·2014
    Same author

    Molecular systematics of the Simulium jenningsi species group (Diptera: Simuliidae), with three new fast-evolving nuclear genes for phylogenetic inference.

    Molecular phylogenetics and evolution·2014
    Same author

    Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a model.

    Psychological medicine·2011
    Same author

    Role of SNAREs and H+-ATPase in the targeting of proton pump-coated vesicles to collecting duct cell apical membrane.

    Kidney international·2007

    Area of Science:

    • Physiology
    • Renal Physiology
    • Reproductive Physiology

    Background:

    • Pregnancy is associated with significant physiological adaptations, including changes in fluid and electrolyte balance.
    • Understanding kidney function during pregnancy is crucial for managing maternal health.

    Purpose of the Study:

    • To define individual nephron function and salt and fluid reabsorption in term pregnant rats.
    • To investigate the mechanisms of sodium retention during pregnancy.

    Main Methods:

    • Standard micropuncture techniques were used in pregnant and non-pregnant rats.
    • Glomerular filtration rate (GFR) and tubular reabsorption of sodium (Na) and potassium were measured.
    • Clearance studies were performed in anesthetized rats.

    Main Results:

    • No significant differences in GFR or nephron GFR were observed between pregnant and non-pregnant rats.
    • Fractional and absolute Na reabsorption in the proximal tubule and loop of Henle were similar.
    • While fractional Na reabsorption was higher in the distal tubule of pregnant rats, this was not statistically significant.
    • Absolute delivery and reabsorption beyond the late distal tubule were greater in non-pregnant rats.
    • Distal nephron potassium secretion was similar in both groups.
    • In clearance studies, pregnant rats showed significantly higher GFR and tubular Na reabsorption.

    Conclusions:

    • Pregnant rats maintain glomerular tubular balance.
    • Potassium handling along the superficial nephron is unaffected by pregnancy.
    • Sodium retention in pregnancy results from a failure to inhibit tubular sodium reabsorption, contrary to the expected response during extracellular volume expansion.

    Related Experiment Videos