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Related Experiment Videos

Clinical experience with implant contraception

E Coutinho

    Contraception
    |October 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Subdermal implants containing synthetic progestagens demonstrate high contraceptive effectiveness and acceptability in clinical trials. Abnormal bleeding patterns remain a key challenge, prompting research into combination estrogen-progestogen implants.

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    Area of Science:

    • Reproductive endocrinology
    • Contraceptive technology
    • Biomaterials science

    Background:

    • Subdermal implants offer a long-acting reversible contraception (LARC) method.
    • Polysiloxane (Silastic) capsules are a common delivery system for progestagens.
    • Previous research has explored various progestagens for contraceptive efficacy.

    Purpose of the Study:

    • To evaluate the contraceptive effectiveness of subdermal implants containing synthetic progestagens.
    • To assess the acceptability and continuation rates of these progestagen implants.
    • To identify the primary disadvantages and explore potential improvements.

    Main Methods:

    • Clinical trials involving approximately 5000 women over 8 years.
    • Use of subdermal polysiloxane (Silastic) capsules containing various synthetic progestagens.

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  • Varied number of capsules and release rates to adjust duration from 6 months to 6 years.

    • Main Results:

    • High rates of contraceptive effectiveness and user acceptability were observed.
    • One-year continuation rates generally exceeded 80%.
    • Abnormal bleeding patterns emerged as the main disadvantage.

    Conclusions:

    • Subdermal progestagen implants are highly effective and acceptable LARC methods.
    • Addressing abnormal bleeding is crucial for improving patient satisfaction.
    • Combination estrogen-progestogen implants are under investigation to mitigate bleeding issues.