Experimental studies of the abuse potential of d, l-glaucine. 1.5-phosphate in rhesus monkeys

d-Glaucine is an alkaloid derived from Glaucium flavum, which is as effective as codeine as an antitussive. d, l-Glaucine. 1.5 phosphate is a synthetic compound related to d-glaucine. The ability of d, l-glaucine.1.5 phosphate to maintain responding in rhesus monkeys was assessed in 2 procedures. In the first responding was maintained under a fixed-ratio 10 schedule of codeine delivery during daily 3-hr sessions. When d, l-glaucine.1.5 phosphate (0.05-0.4 mg/kg) was substituted for codeine, responding was not maintained. In the second procedure, monkeys given 23-hr/day access to 0.5-1.0 mg/kg under a fixed-ratio schedule did not self-administer d,l-glaucine.1.5 phosphate above saline levels even after a 21-day period of programmed injections. Following the period of programmed injections, there were not signs of opiate withdrawal following the administration of naloxone. These results indicate that the abuse potential of d,l-glaucine.1.5 phosphate is low relative to codeine.