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Malignant catarrhal fever virus infectivity in rabbit macrophages and monocytes
Veterinary Research Communications
|September 1, 1981
Abstract:
Malignant catarrhal fever virus (MCFV) infectivity was demonstrated in macrophages/monocytes collected from MCFV-infected rabbits. Thus, in addition to lymphocytes, macrophages and monocytes are probably involved in the pathogenesis of MCFV and could account for the widespread dissemination of MCFV, the very high mortality rate and the immunosuppression observed in MCFV-infected animals.
Insights
Malignant catarrhal fever virus (MCFV) infects macrophages and monocytes in rabbits. These cells likely contribute to MCFV
Area of Science:
- Veterinary Virology
- Immunology
Background:
- Malignant catarrhal fever virus (MCFV) causes severe disease in various ungulates.
- The cellular tropism and role of different immune cells in MCFV pathogenesis are not fully elucidated.
Purpose of the Study:
- To investigate the infectivity of MCFV in macrophages and monocytes from infected rabbits.
- To determine the potential role of these myeloid cells in MCFV dissemination and disease.
Main Methods:
- Isolation and culture of peripheral blood mononuclear cells (PBMCs) from MCFV-infected rabbits.
- Detection of MCFV infectivity within isolated macrophage/monocyte populations.
Main Results:
- MCFV infectivity was successfully demonstrated in macrophages and monocytes derived from infected rabbits.
- These findings indicate that myeloid cells are susceptible to MCFV infection.
Conclusions:
- Macrophages and monocytes, in addition to lymphocytes, are likely involved in MCFV pathogenesis.
- Involvement of these cells may explain the widespread virus dissemination, high mortality, and immunosuppression seen in MCFV-infected animals.