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[Central nervous system malformations in autopsy material]

A Tennstedt, M Gutermann, D Schreiber

    Zentralblatt Fur Allgemeine Pathologie U. Pathologische Anatomie
    |January 1, 1982
    PubMed
    Summary
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    Central nervous system malformations occurred in 5.5% of pediatric autopsies over 20 years. Hydrocephalus, migration disturbances, and dysraphias were the most common, impacting mortality and distribution.

    Area of Science:

    • Neurology
    • Developmental Biology
    • Pediatric Pathology

    Context:

    • Autopsy data from 1960-1979 involving stillborn and live-born children up to 16 years.
    • Analysis of 4561 autopsy reports over a two-decade period.
    • Focus on central nervous system (CNS) malformations.

    Purpose:

    • To classify and analyze the incidence of CNS malformations in pediatric autopsies.
    • To investigate the nature, combinations, and sex differences of these malformations.
    • To assess the impact of CNS malformations on mortality and their distribution over time and territory.

    Summary:

    • A 5.5% prevalence of central nervous system malformations was identified in 4561 pediatric autopsies.
    • Hydrocephalus was the most frequent malformation, followed by neural tube defects (dysraphias) and migration disturbances.

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  • The study details malformation classifications, combinations, sex-specific patterns, and mortality relevance.

    • Impact:

    • Provides historical epidemiological data on pediatric CNS malformations.
    • Highlights the significant contribution of specific malformations like hydrocephalus to pediatric mortality.
    • Informs understanding of the distribution and trends of congenital neurological disorders.