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Naloxone and ethanol intoxication

R Askenasi, J Fontaine

    Acta Anaesthesiologica Belgica
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Naloxone, an opioid antagonist, was tested as an antidote for acute ethanol intoxication in mice. High doses of naloxone did not effectively counteract ethanol

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Neuroscience

    Background:

    • Naloxone is proposed as an antidote for acute ethanol intoxication.
    • Existing experimental and clinical evidence supporting this claim is contradictory and inconclusive.

    Purpose of the Study:

    • To investigate the efficacy of naloxone in antagonizing ethanol's effects in a mouse model.
    • To compare naloxone's antagonism of ethanol with its known effects on morphine intoxication.

    Main Methods:

    • Administration of naloxone at varying doses to mice.
    • Assessment of ethanol intoxication effects.
    • Comparison of results with morphine intoxication models.

    Main Results:

    • Naloxone, even at a high dose of 5 mg/kg, demonstrated poor efficacy in antagonizing ethanol intoxication in mice.

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  • The antagonism effects were less pronounced compared to morphine intoxication.

    • Conclusions:

    • Naloxone is not an effective antidote for acute ethanol intoxication in mice.
    • Further research is needed to clarify the complex interactions between naloxone and ethanol.