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Sexual dysfunction and clomipramine

K C Quirk, T R Einarson

    Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
    |April 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Clomipramine can cause orgasmic inhibition in patients with depression and obsessive-compulsive disorder. Switching to desipramine or adjusting dosage times may resolve this sexual dysfunction.

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    Area of Science:

    • Psychiatry
    • Pharmacology
    • Neuroscience

    Background:

    • Clomipramine is a tricyclic antidepressant effective for depression and obsessive-compulsive disorder.
    • Sexual dysfunction is a common side effect of antidepressant medications.

    Observation:

    • Three cases (one male, two female) of clomipramine-induced orgasmic inhibition were observed.
    • Patients experienced inhibited orgasm despite restored libido during depression treatment.

    Findings:

    • Clomipramine therapy led to orgasmic dysfunction in patients with depression and obsessive-compulsive features.
    • Switching to desipramine resolved sexual dysfunction in two patients.
    • Dosage timing adjustments helped one patient manage the side effect.

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    Implications:

    • Clomipramine's anticholinergic and anti-adrenergic properties may cause orgasmic inhibition.
    • Clinicians should monitor for sexual side effects during clomipramine treatment.
    • Alternative medications like desipramine may be suitable for patients experiencing this dysfunction.