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Related Experiment Videos

Galactorrhea in oral contraceptive users

G Holtz

    The Journal of Reproductive Medicine
    |April 1, 1982
    PubMed
    Summary
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    Nine percent of women using oral contraceptives (OCs) experienced galactorrhea. This condition in non-breastfeeding OC users often indicates underlying pituitary issues, warranting further medical evaluation.

    Area of Science:

    • Endocrinology
    • Reproductive Health
    • Oncology

    Background:

    • Oral contraceptives (OCs) are widely used for birth control.
    • Galactorrhea, or abnormal milk production, can occur in women.

    Purpose of the Study:

    • To investigate the incidence of galactorrhea in women using combination estrogen/progestin oral contraceptives.
    • To assess the association between galactorrhea and pituitary pathology in this population.

    Main Methods:

    • One hundred women using OCs for at least six months were screened for galactorrhea.
    • Twelve OC users with galactorrhea underwent evaluation for pituitary microadenomas, including hormonal assays and imaging.

    Main Results:

    • Galactorrhea was present in 9% of the OC users.
    Keywords:
    Age FactorsBiologyCentral Nervous SystemCentral Nervous System EffectsContraceptionContraception ContinuationContraceptive Methods--side effectsDiseasesEndocrine SystemFamily PlanningGalactorrheaGonadotropinsGonadotropins, PituitaryHormonesMenstrual CycleOral Contraceptives, CombinedOral Contraceptives--side effectsPhysiologyPituitary HormonesPopulation CharacteristicsProlactin--analysisPuerperal Disorders

    Related Experiment Videos

  • The incidence of galactorrhea did not significantly correlate with age, gravidity, duration of OC use, or estrogen content.
  • Among the twelve OC users with galactorrhea, several showed evidence of pituitary abnormalities, including prolactinomas and other microadenomas.

    • Conclusions:

    • Galactorrhea in women using oral contraceptives who have not breastfed is frequently linked to significant intrasellar pathology.
    • This finding suggests that galactorrhea in this context should prompt further diagnostic evaluation for pituitary abnormalities.