Attempted tumor induction with agaritine in mice

Agaritine, a constituent of the cultivated mushroom of commerce Agaricus bisporus, was administered at concentrations of 0.0625 and 0.03125% in drinking water daily for life to randomly bred Swiss mice. Consumption of the chemical resulted in no detectable carcinogenic action under the experimental conditions. During the course of the experiment, however, a substantial number of animals developed convulsive seizures.