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Related Experiment Videos

Attempted tumor induction with agaritine in mice

B Toth, C R Raha, L Wallcave

    Anticancer Research
    |January 1, 1981
    PubMed
    Summary

    Agaritine, a compound in Agaricus bisporus mushrooms, did not cause cancer in mice. However, daily consumption led to a significant number of animals experiencing convulsive seizures during the study.

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    Toxicology and applied pharmacology·2019

    Area of Science:

    • Toxicology
    • Mushroom Science
    • Animal Studies

    Background:

    • Agaritine is a naturally occurring compound found in the common cultivated mushroom, Agaricus bisporus.
    • Previous research has explored the potential health effects of mushroom constituents.

    Purpose of the Study:

    • To investigate the carcinogenic potential of agaritine.
    • To observe any adverse health effects associated with long-term agaritine consumption in a rodent model.

    Main Methods:

    • Swiss mice were administered agaritine daily for life at two different concentrations (0.0625% and 0.03125%) in their drinking water.
    • The study monitored the animals for the development of tumors and other health issues.

    Main Results:

    • No evidence of carcinogenic activity was detected in the mice exposed to agaritine under the study's conditions.
    • A notable incidence of convulsive seizures was observed in a significant proportion of the animals during the experimental period.

    Conclusions:

    • Agaritine did not demonstrate carcinogenic effects in this mouse model.
    • Long-term exposure to agaritine may be associated with neurological side effects, specifically seizures.

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