[Bromopride: pharmacokinetics in dogs (author's transl)]

The pharmacokinetics of bromopride were studied in dogs following a single oral or i.v. administration. The calculation of the pharmacokinetic parameters was based on an open two-compartment model after i.v. injection and on an open one-compartment model when the drug was given by mouth. Serum elimination half-life following i.v. injection was shown to exceed that after oral ingestion. Bromopride was rapidly transformed into the monodeethyl metabolite accounting for the largest fraction at 4 h after administration.