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Human malignant diffuse mesothelioma: submicroscopic study on the epithelial component

F Osculati, C Parravicini, S Cinti

    Journal of Submicroscopic Cytology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    Submicroscopic analysis revealed malignant mesothelioma cells possess distinct features like prominent RER and Golgi. These cellular characteristics may explain the tumor

    Area of Science:

    • Oncology
    • Cell Biology
    • Pathology

    Background:

    • Malignant diffuse mesothelioma is a rare cancer originating in the mesothelium.
    • Understanding the ultrastructural characteristics of mesothelioma cells is crucial for diagnosis and understanding pathogenesis.
    • Previous studies have not fully elucidated the specific subcellular features associated with hyaluronic acid production in this cancer.

    Purpose of the Study:

    • To investigate the submicroscopic (ultrastructural) features of well-differentiated malignant diffuse mesothelioma cells.
    • To correlate observed cellular structures with the known ability of mesothelioma to produce hyaluronic acid.
    • To explore the significance of specific extracellular and intracellular bodies within mesothelioma.

    Main Methods:

    • Submicroscopic analysis (electron microscopy) of eight cases of malignant diffuse mesothelioma.

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  • Utilized postfixation with osmium ferrocyanide to visualize extracellular components.
  • Examined cellular organelles, including the rough endoplasmic reticulum (RER) and Golgi apparatus.

    • Main Results:

    • Well-differentiated neoplastic mesothelioma cells exhibited a prominent RER and a conspicuous Golgi system, differentiating them from normal mesothelium.
    • An amorphous extracellular substance was observed after osmium ferrocyanide postfixation.
    • Groups of membrane-bound dense bodies were identified in seven out of eight cases.

    Conclusions:

    • The prominent RER and Golgi system in malignant mesothelioma cells likely contribute to their high capacity for hyaluronic acid synthesis.
    • The observed extracellular amorphous substance may be related to hyaluronic acid production.
    • The presence of membrane-bound dense bodies warrants further investigation into their role in mesothelioma.