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Plasma somatomedin activity in an infant with Beckwith Wiedemann syndrome

I K Ashton, A Aynsley-Green

    Early Human Development
    |February 1, 1978
    PubMed

    Insights

    Elevated somatomedin activity and growth hormone levels in an infant with Beckwith-Wiedemann syndrome may contribute to excessive fetal growth. These levels normalized by 8 months, with growth parameters also returning to normal ranges.

    Area of Science:

    • Pediatric Endocrinology
    • Genetics and Developmental Biology

    Background:

    • Beckwith-Wiedemann syndrome is associated with overgrowth.
    • The role of specific growth factors in fetal overgrowth is not fully understood.

    Observation:

    • A neonate diagnosed with Beckwith-Wiedemann syndrome exhibited significantly elevated birth weight and length, exceeding the 97th percentile.
    • Plasma samples at birth revealed high levels of both growth hormone and somatomedin activity compared to control groups.

    Findings:

    • At 8 months of age, the child's growth hormone and somatomedin activity normalized, with weight and length falling to the 75th percentile.
    • The initial elevated somatomedin activity correlated with the excessive fetal growth observed.

    Implications:

    • High somatomedin activity is a potential contributor to the characteristic overgrowth in Beckwith-Wiedemann syndrome.
    • Monitoring hormonal levels in infancy may provide insights into growth patterns and potential interventions.

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