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Related Experiment Videos

[Transsexualism and the H-Y antigen]

W Eicher, M Spoljar, J D Murken

    Fortschritte Der Medizin
    |January 15, 1981
    PubMed
    Summary

    Transsexual individuals often show incongruous H-Y antigen status, aligning with gender identity rather than biological sex. This finding suggests a potential role for H-Y antigen in understanding gender identity development.

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    Area of Science:

    • Immunogenetics
    • Endocrinology
    • Sexology

    Context:

    • H-Y antigen, a male-specific histocompatibility antigen, has been studied in relation to transsexualism since 1979.
    • Previous research suggested a potential link between H-Y antigen expression and gender identity.

    Purpose:

    • To investigate the H-Y antigen status in a cohort of male-to-female and female-to-male transsexual individuals.
    • To determine if H-Y antigen expression correlates with gender identity or biological sex characteristics.

    Summary:

    • Analyzed H-Y antigen expression in 61 transsexuals using the Goldberg cytotoxicity assay.
    • Found incongruous H-Y antigen status in 55 cases (91%), aligning with gender identity in most instances.
    • Male-to-female transsexuals were predominantly H-Y negative, while female-to-male transsexuals were predominantly H-Y positive.

    Impact:

    • These findings challenge traditional understandings of H-Y antigen function and sex determination.
    • Suggests novel considerations for the pathogenesis of gender dysphoria and the biological underpinnings of gender identity.
    • May influence future research into the genetic and immunological factors involved in transsexualism.

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