Liver biopsy diagnosis of unsuspected or unconfirmed lymphoproliferative or myeloproliferative disorders

Review of 2,400 consecutive percutaneous liver biopsy specimens revealed 3 (0.1%) with morphologically unequivocal but clinically unsuspected or unconfirmed malignant lymphomas and 20 (0.8%) with infiltrates suggestive of or compatible with lymphoproliferative or myeloproliferative disorders. These diagnoses were subsequently confirmed in 7 of the 20 cases, whereas in 4 the nature of the infiltrates and the outcome remain undecided. In the remaining 9 cases, inflammatory sinusoidal infiltrates had been erroneously suspected to represent lymphoproliferative or myeloproliferative disorders.