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Vasoconstriction and d-amphetamine-induced hypothermia

S Yehuda, R L Carasso, Y Ben-Uriah

    The International Journal of Neuroscience
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

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    d-amphetamine causes hypothermia in rats. While vasoconstriction and vasodilation are involved in temperature regulation, they do not explain how d-amphetamine lowers body temperature.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Physiology

    Background:

    • d-amphetamine is known to affect body temperature.
    • Thermoregulation involves complex physiological processes, including vasoconstriction and vasodilation.
    • The peripheral mechanisms underlying d-amphetamine-induced hypothermia remain unclear.

    Purpose of the Study:

    • To investigate the role of peripheral vasoconstriction and vasodilation in d-amphetamine-induced hypothermia.
    • To determine if pharmacological induction of vasoconstriction or vasodilation modifies the hypothermic effect of d-amphetamine.

    Main Methods:

    • Rats were administered d-amphetamine.
    • Vasoconstriction was induced using aramine, and vasodilation using neprasol.
    • Body temperature changes were monitored in rats exposed to a cold environment (4 degrees C).

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    Main Results:

    • Both aramine and neprasol enhanced d-amphetamine-induced hypothermia in rats at 4 degrees C.
    • However, neither drug altered the d-amphetamine-induced hypothermia.
    • These findings suggest peripheral vasoconstriction is not the primary mechanism.

    Conclusions:

    • Vasoconstriction and vasodilation are important in thermoregulation but do not solely explain d-amphetamine-induced hypothermia.
    • Peripheral mechanisms like metabolic rate, motor activity, food intake, and vasoconstriction do not account for the observed hypothermia.
    • The precise peripheral mechanism of d-amphetamine-induced hypothermia remains to be elucidated.