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Related Experiment Videos

Improved pyeloureteral visualization using glucagon during experimental intravenous urography

B J Hillman, T W Ovitt, J W Doering

    Investigative Radiology
    |July 1, 1980
    PubMed
    Summary

    Glucagon administration effectively improved pyelocalyceal distention and ureteral visualization during intravenous urography in dogs. This study suggests glucagon as a potential alternative to abdominal compression for enhanced imaging.

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    Area of Science:

    • Radiology
    • Pharmacology
    • Veterinary Medicine

    Background:

    • Intravenous urography (IVU) traditionally uses abdominal compression for optimal pyelocalyceal system distention.
    • Difficulties associated with abdominal compression necessitate exploring alternative methods for improved IVU imaging.

    Purpose of the Study:

    • To evaluate glucagon as an alternative to abdominal compression for enhancing pyelocalyceal distention and ureteral visualization in IVU.
    • To assess the efficacy of glucagon in improving the diagnostic quality of urograms.

    Main Methods:

    • The study involved six greyhound dogs.
    • Glucagon was administered intravenously to assess its effect on ureteral peristalsis and pyelocalyceal distention.
    • Urography was performed with and without glucagon administration for comparative analysis.

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    Main Results:

    • Intravenous glucagon injection resulted in transient cessation of ureteral peristalsis.
    • Statistically significant improvements in the visualization of collecting systems and ureters were observed when IVU was performed with glucagon.
    • Both objective and subjective analyses confirmed the enhanced demonstration of urinary tract structures.

    Conclusions:

    • Glucagon administration significantly improves pyelocalyceal distention and ureteral visualization during intravenous urography in dogs.
    • The findings support the experimental use of glucagon in human subjects as a viable alternative to abdominal compression for IVU.