Evidence supporting an antibody mediation of contrast media reactions

Despite past doubts of the existence of antibodies to radiographic contrast material, there is now both clinical and experimental data to indicate that such antibodies do exist and that in certain individuals the antibodies may lead to severe or even fatal contrast media reactions. This article will detail the accumulated evidence supporting an allergic theory of contrast media toxicity in an attempt to stimulate interest and further investigation into this previously abandoned theory of mediation.