Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The structure of neurophysin

J Drenth

    The Journal of Biological Chemistry
    |March 25, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Neurophysin, a hormone carrier, shares structural similarities with plant proteins, suggesting a two-domain structure. This research proposes a novel linkage of hormones to its COOH terminus.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [From bluestocking to vamp; images reflecting the view on female doctors after 1850].

    Nederlands tijdschrift voor geneeskunde·2009
    Same author

    Molecular characterization of the waxy locus in sorghum.

    Genome·2008
    Same author

    Resistance gene analogues in sugarcane and sorghum and their association with quantitative trait loci for rust resistance.

    Genome·2005
    Same author

    Homologues of the maize rust resistance gene Rp1-D are genetically associated with a major rust resistance QTL in sorghum.

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2004
    Same author

    Identifications of two different mechanisms for sorghum midge resistance through QTL mapping.

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2003
    Same author

    Direct sequencing of RAPD fragments using 3'-extended oligonucleotide primers and dye terminator cycle-sequencing.

    Nucleic acids research·1999
    Same journal

    Isotope-Edited ESEEM: A New Method for Probing Copper Binding Sites in Neurodegenerative Proteins.

    The Journal of biological chemistry·2026
    Same journal

    Introduction to the Thematic Review Series on Intracellular Protein Degradation. The ubiquitous biology of intracellular protein degradation: a tribute to Alfred L. ("Fred") Goldberg.

    The Journal of biological chemistry·2026
    Same journal

    Correction: Aromatic residue-rich amino-terminal segments of temporin L self-assemble into collagen-mimetic peptides with cell-adhesion properties.

    The Journal of biological chemistry·2026
    Same journal

    YhbO is a DJ-1 family glyoxalase and α-oxoaldehyde hydratase that confers resistance to reactive carbonyl stress (112).

    The Journal of biological chemistry·2026
    Same journal

    ARMH3 acts as a central scaffold at the Golgi/TGN through interactions with Arl5, GBF1, and PI4KB.

    The Journal of biological chemistry·2026
    Same journal

    PAX8 controls proximal tubule epithelial identity and stress response through epigenetic modification of distal regulatory elements.

    The Journal of biological chemistry·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Structural Biology
    • Protein Chemistry

    Background:

    • Neurophysin is a carrier protein for peptide hormones like oxytocin and vasopressin.
    • Understanding neurophysin's structure is crucial for elucidating hormone transport mechanisms.

    Purpose of the Study:

    • To compare the half-cystine positions in neurophysin with those in cystine-rich plant proteins.
    • To propose a structural model for neurophysin and its hormone binding.

    Main Methods:

    • Comparative analysis of amino acid sequences, focusing on half-cystine residues.
    • Structural modeling based on sequence homology.

    Main Results:

    • Neurophysin exhibits structural homology to domains found in wheat germ agglutinin.

    Related Experiment Videos

  • A two-domain structure for neurophysin is proposed, with each domain resembling wheat germ agglutinin domains.
  • A model suggests hormone (oxytocin or vasopressin) linkage to the COOH terminus of proneurophysin.

    • Conclusions:

    • Neurophysin's structure is conserved across different biological kingdoms.
    • The proposed domain structure and hormone linkage offer new insights into neurophysin function.