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Laryngeal electromyography in multiple system atrophy with autonomic failure
Journal of Neurology, Neurosurgery, and Psychiatry
|January 1, 1981
Summary
New electromyographic studies reveal posterior crico-arytenoid muscle denervation in multiple system atrophy (MSA) patients. This finding helps differentiate MSA from other extra-pyramidal syndromes using laryngeal muscle electrical activity.
Area of Science:
- Neurology
- Electrophysiology
- Laryngeal Electromyography
Background:
- Multiple system atrophy (MSA) is a progressive neurodegenerative disorder.
- Laryngeal muscle dysfunction can contribute to symptoms in MSA.
- Accurate diagnosis and differentiation from other extra-pyramidal syndromes are clinically important.
Purpose of the Study:
- To investigate laryngeal muscle denervation in patients with multiple system atrophy (MSA) using electromyography (EMG).
- To compare EMG findings in MSA with those in patients with other extra-pyramidal syndromes.
Main Methods:
- Utilized a novel surface electrode technique for electromyography (EMG).
- Assessed denervation in posterior crico-arytenoid, interarytenoid muscles, and crico-pharyngeal sphincter.
- Compared findings in five MSA patients with those in patients with other extra-pyramidal syndromes.
Main Results:
- Unequivocal evidence of posterior crico-arytenoid muscle denervation was found in all five MSA patients.
- Three MSA patients also showed denervation of the interarytenoid muscle or crico-pharyngeal sphincter.
- One-third of patients with other extra-pyramidal syndromes had minor EMG abnormalities, distinct from those in MSA.
Conclusions:
- Surface electrode EMG can detect laryngeal muscle denervation in MSA.
- These findings suggest EMG can aid in differentiating MSA from other extra-pyramidal disorders.
- Laryngeal muscle denervation is a characteristic finding in MSA.