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Bound antibody in multiple sclerosis brains

P D Mehta, S Frisch, H Thormar

    Journal of the Neurological Sciences
    |January 1, 1981
    PubMed
    Summary
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    Researchers found bound immunoglobulin G (IgG) in multiple sclerosis (MS) brains, suggesting antigen-antibody complexes. Alkaline extraction yielded more IgG than acidic extraction from MS brain tissue.

    Area of Science:

    • Neuroimmunology
    • Neuropathology

    Background:

    • Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system.
    • The role of immunoglobulin G (IgG) deposition in MS pathogenesis is an area of ongoing research.

    Purpose of the Study:

    • To investigate the presence and characteristics of bound IgG in the brains of MS patients.
    • To explore potential antigen-antibody complex formation in MS.

    Main Methods:

    • Homogenization and centrifugation of autopsy brain tissues (MS patients and controls).
    • Extraction of bound IgG using acidic and alkaline pH buffers.
    • Analysis of eluates using isoelectric focusing.

    Main Results:

    • Significant levels of bound IgG were detected in MS brains, with higher yields obtained using alkaline pH extraction.

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  • Bound IgG extractable at acidic pH was largely absent in control brains.
  • Isoelectric focusing revealed oligoclonal IgG bands in MS brain eluates, partially matching unbound IgG.

    • Conclusions:

    • The findings suggest the presence of antigen-antibody complexes in MS brains.
    • Bound IgG may play a role in the neuropathology of MS.
    • Differential extraction methods highlight variations in IgG binding characteristics.