Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cost evaluation of alternative pharmaceutical tableting processes by simulation

R M Franz, G S Banker, J R Buck

    Journal of Pharmaceutical Sciences
    |June 1, 1980
    PubMed
    Summary

    This study developed a simulation model to evaluate tableting process costs and times. The model helps optimize manufacturing by identifying key variables affecting cost-time relationships for better decision-making.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    On the Diagnosis of Phthisis Pulmonalis; Being an Extract from a Lecture Delivered at the General Dispensary, Louisville, Ky.

    Western journal of medicine and surgery·2024
    Same author

    Cases of Fever with Remarks.

    Western journal of medicine and surgery·2024
    Same author

    Lectures on Diseases of the Chest.

    Western journal of medicine and surgery·2024
    Same author

    Lectures on Diseases of the Chest.

    Western journal of medicine and surgery·2024
    Same author

    Lectures on Diseases of the Chest.

    Western journal of medicine and surgery·2024
    Same author

    Lectures on Physical Diagnosis.

    Western journal of medicine and surgery·2024

    Area of Science:

    • Pharmaceutical Manufacturing
    • Industrial Engineering
    • Computational Modeling

    Background:

    • Tableting is a critical pharmaceutical manufacturing process.
    • Optimizing tableting for cost and time efficiency is essential for competitiveness.
    • Existing methods for evaluating tableting processes lack comprehensive cost-time analysis.

    Purpose of the Study:

    • To develop a simulation model for evaluating tableting processes.
    • To estimate processing times and associated costs.
    • To identify key input variables influencing cost-time relationships.

    Main Methods:

    • Developed a simulation model using FORTRAN and GASP IV.
    • Verified the computer program for accuracy.
    • Conducted experiments by varying input parameters like drying method, batch size, and labor rate.

    Related Experiment Videos

  • Performed analysis of variance and developed regression equations.

    • Main Results:

    • Three regression equations were developed, describing the relationship between input variables and processing cost/time.
    • Graphs generated from regression equations facilitated determination of minimum costs, times, and breakeven points.
    • Identified significant input variables affecting cost-time relationships in tableting.

    Conclusions:

    • The simulation model provides a robust method for analyzing tableting process economics.
    • Results aid in making informed decisions regarding tableting procedures before implementation.
    • The model enables graphic representation for process evaluation and optimization.