Eisenmenger syndrome: measurement of left atrial volume

Three cases with Eisenmenger syndrome were reported. Two of then were infants and one was adolescent. In the infant cases, the left atrial volume was small and the left atrial volume change ratio was large. In the adolescent case, the left atrial volume was large and the left atrial volume change ratio was reduced. In the adolescent case, the decrease in the left atrial volume change ratio probably caused the pulmonary hypertension, but in the infant cases, the left atrial volume change ratio was not decreased and therefore this cannot be the cause of the pulmonary hypertension. The brain damage with microcephaly might play a role in the development of the high pulmonary vascular resistance.