[Pharmacokinetics of cefadroxil in rats: comparison of fasting and non-fasting (author's transl)]

A single dose 50 mg/kg of cefadroxil was administered orally to rats in fasting and non-fasting. In both fasting and non-fasting, the serum levels of cefadroxil were higher than those of cephalexin. In fasting, the biological half-life (T 1/2) of cefadroxil was longer than that of cephalexin. This indicates its prolonged durable action. Ingestion of cefadroxil with food affected the serum level less than that of cephalexin with food, and the serum levels of cefadroxil in non-fasting were same as those of cephalexin in fasting.