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Age-associated pathological changes in male rats

B J Cohen, M R Anver, D H Ringler

Federation Proceedings

|December 1, 1978

Summary

Understanding spontaneous lesions in aging rats is crucial for accurate research. Comparing outbred Crl:CD(SD)BR and inbred F344 male rats revealed significant age-associated pathological changes impacting experimental variability.

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Area of Science:

Gerontology
Comparative Pathology
Animal Models in Aging Research

Background:

Accurate interpretation of aging research results depends on understanding spontaneous lesions in specific rat stocks and strains.
Variability in experimental outcomes can arise from age-associated pathological changes in laboratory animals.

Purpose of the Study:

To compare age-associated pathological changes in outbred Crl:CD(SD)BR and inbred F344 male rats.
To assess the impact of spontaneous lesions on experimental variability in aging studies.

Main Methods:

Postmortem examination of 113 outbred Crl:CD(SD)BR male retired breeder rats (12-39 months old).
Comparison with published data on 122 virgin male F344 rats (12-33 months old).

Main Results:

Both rat groups exhibited numerous degenerative, inflammatory, and neoplastic lesions.
The prevalence and severity of many lesions suggest they contribute significantly to experimental variability.
Lesions can directly and indirectly affect target organs, influencing study outcomes.

Conclusions:

Defining the prevalence of spontaneous lesions in aging rat stocks/strains is essential for research.
Postmortem examination of representative animal groups at various ages is recommended.
Antemortem screening may help manage variability or select for specific research interests.

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