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Related Experiment Videos

Hemostasis in typhoid fever

M Miró-Quesada, E Crosby, E Gotuzzo

    The Johns Hopkins Medical Journal
    |February 1, 1981
    PubMed
    Summary
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    Typhoid fever frequently causes hemostatic abnormalities, including low fibrinogen levels, potentially due to disseminated intravascular coagulation. Bleeding risks in these patients correlate with clotting test results.

    Area of Science:

    • Hematology
    • Infectious Diseases
    • Clinical Medicine

    Background:

    • Typhoid fever is a serious systemic infection.
    • Hemostasis, the process of stopping bleeding, can be affected by infections.
    • Previous studies have not fully characterized hemostatic abnormalities in typhoid fever.

    Purpose of the Study:

    • To prospectively define hemostatic abnormalities in patients with typhoid fever.
    • To establish new normal fibrinogen levels for typhoid fever patients.
    • To investigate the relationship between fibrinogen levels, disseminated intravascular coagulation, and bleeding in typhoid fever.

    Main Methods:

    • Prospective study of 56 patients diagnosed with typhoid fever.
    • Evaluation of hemostasis in vivo and in vitro.

    Related Experiment Videos

  • Comparison of patient fibrinogen levels with normal controls.
  • Assessment of clotting abnormalities and clinically significant bleeding.

    • Main Results:

    • Hemostatic abnormalities were frequently observed in typhoid fever patients.
    • A higher fibrinogen level was established as normal for typhoid fever patients.
    • Low fibrinogen levels correlated with other hemostatic abnormalities.
    • Disseminated intravascular coagulation affected 20% of patients, often mildly.
    • Clinically significant bleeding occurred in 18 patients and correlated with clotting abnormalities.

    Conclusions:

    • Hemostatic abnormalities are common in typhoid fever.
    • Low fibrinogen may indicate disseminated intravascular coagulation in typhoid fever.
    • Clotting abnormalities are associated with bleeding in typhoid fever patients.