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Liver in leprosy--I. Functional changes

K Robins, T Vijayakumar, T Gopinath

    Leprosy in India
    |July 1, 1980
    PubMed
    Summary
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    See all related articles

    Leprosy patients often show abnormal liver function, particularly a reversed albumin/globulin ratio, more common in lepromatous leprosy. Dapsone treatment normalized some liver enzymes and globulin levels in leprosy patients.

    Area of Science:

    • Medical Microbiology
    • Hepatology
    • Clinical Biochemistry

    Background:

    • Leprosy, a chronic infectious disease, can affect various organs, including the liver.
    • Liver function abnormalities are frequently observed in leprosy patients, impacting disease management and prognosis.

    Purpose of the Study:

    • To investigate liver function test abnormalities in leprosy patients.
    • To compare liver function between treated, untreated, and clinically quiescent leprosy patients.
    • To assess the impact of Dapsone (DDS) therapy on liver function in leprosy.

    Main Methods:

    • Liver function tests (LFTs) were performed on 79 leprosy patients (treated, untreated, quiescent).
    • Specific LFTs included albumin/globulin ratio, transaminases, alkaline phosphatase, and serum cholesterol.

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  • 10 untreated tuberculoid leprosy patients were reassessed after 6 months of Dapsone therapy.
  • Comparison groups included untreated leprosy patients and 20 healthy adults.

    • Main Results:

    • A reversed albumin/globulin ratio was the most common abnormality, more prevalent in lepromatous leprosy.
    • Dapsone therapy led to reduced serum globulin levels.
    • Transaminases and alkaline phosphatase showed no change in untreated patients but increased with Dapsone treatment.
    • Mean serum cholesterol levels were lower in leprosy patients compared to controls.

    Conclusions:

    • Leprosy is associated with distinct liver function test alterations, notably the albumin/globulin ratio reversal.
    • Dapsone therapy influences liver enzyme profiles and globulin levels in leprosy patients.
    • Monitoring liver function is crucial during leprosy treatment, especially with Dapsone therapy.