Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanisms of development and aging

B E Wright, P F Davison

    Mechanisms of Ageing and Development
    |March 1, 1980
    PubMed
    Summary

    Current aging research focuses too much on simple methods. A complex SYSTEMS analysis is needed to understand the intricate biochemical mechanisms of aging.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Laparoscopic cholecystectomy accompanied by simultaneous umbilical hernia repair.

    Journal of postgraduate medicine·2007
    Same author

    Chronic traumatic diaphragmatic hernia with pericardial rupture and associated gastroesophageal reflux.

    Hernia : the journal of hernias and abdominal wall surgery·2005
    Same author

    Mechanisms by which transcription can regulate somatic hypermutation.

    Genes and immunity·2004
    Same author

    A biochemical mechanism for nonrandom mutations and evolution.

    Journal of bacteriology·2000
    Same author

    Specificity of transcription-enhanced mutations.

    Annals of the New York Academy of Sciences·1999
    Same author

    Hypermutation in derepressed operons of Escherichia coli K12.

    Proceedings of the National Academy of Sciences of the United States of America·1999

    Area of Science:

    • Biochemistry
    • Gerontology
    • Systems Biology

    Background:

    • Aging is a complex biological process.
    • Current research often employs overly simplistic approaches.
    • A deeper understanding of aging mechanisms is lacking.

    Purpose of the Study:

    • To advocate for a shift towards more comprehensive research methodologies in aging.
    • To highlight the inadequacy of current simplistic theories.
    • To propose SYSTEMS analysis as a superior approach.

    Main Methods:

    • Critique of existing aging research paradigms.
    • Advocacy for a holistic, integrated approach.
    • Emphasis on SYSTEMS analysis for biochemical investigation.

    Main Results:

    • Current research on aging is misdirected.
    • Simplistic theories fail to capture aging complexity.
    • SYSTEMS analysis offers a more appropriate framework.

    Conclusions:

    • Understanding aging requires a complex, integrated SYSTEMS analysis.
    • Future research must move beyond simplistic biochemical investigations.
    • A higher level of complexity is essential for aging research.

    Related Experiment Videos