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Thyroid hormones and lipolysis in physically trained rats

A Wirth, G Holm, G Lindstedt

    Metabolism: Clinical and Experimental
    |March 1, 1981
    PubMed
    Summary

    Exercise impacts thyroid hormones and lipolysis. Acute exercise boosts thyroid hormones, while training reduces them, similar to food restriction, affecting fat breakdown. Further research into thyroid hormone effects during training is suggested.

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    Area of Science:

    • Endocrinology
    • Exercise Physiology
    • Metabolism

    Background:

    • Thyroid hormones (T3, T4) regulate metabolism and lipolysis.
    • Exercise and food restriction are known to influence metabolic processes.
    • The interplay between exercise, thyroid hormones, and lipolysis requires further investigation.

    Purpose of the Study:

    • To investigate the effects of acute and chronic exercise on thyroid hormone concentrations and lipolysis in rats.
    • To compare the effects of physical training with moderate food restriction on thyroid hormones and lipolysis.
    • To examine the influence of aging on thyroid hormone levels.

    Main Methods:

    • Rats were subjected to acute exercise, chronic training, or moderate food restriction.
    • Serum concentrations of triiodothyronine (T3), thyroxine (T4), and reverse triiodothyronine (rT3) were measured.

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  • The effect of norepinephrine on lipolysis in vitro was assessed.
  • Thyroid-stimulating hormone (TSH) levels were also analyzed.

    • Main Results:

    • Acute exercise increased T3, T4, and the T3/rT3 ratio, potentiating norepinephrine-induced lipolysis.
    • Chronic training and food restriction decreased T3/rT3 ratio and TSH levels, with T3 potentiating catecholamine-induced lipolysis.
    • Aging led to decreased T3 and increased rT3 serum concentrations.

    Conclusions:

    • Acute and chronic exercise differentially affect peripheral lipolysis and thyroid hormone concentrations.
    • Physical training exhibits effects similar to moderate energy intake restriction regarding thyroid hormones and lipolysis.
    • Changes in peripheral thyroid hormone effects during training warrant increased attention.