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Updated: Aug 10, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Spatial organization of histones and DNA in the nucleosome core particle: a model
Abstract:
We present here an attempt to build up a space-filling model of the nucleosome core particle based on the chemical crosslinking data of Mirzabekov and co-workers (23). It is shown that the models proposed earlier are inconsistent with the results of these authors. The main characteristics of our model are as follows: a) the DNA superhelix contains at least 90 base pairs (bp) per turn; b) the particle has a dyad axis of symmetry; c) the histone octamer may be regarded as consisting of two heterotypic tetramers. The possible shape and function of core histones are discussed in the light of the model.
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