Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating catecholamines and sympathetic activity after head injury

G L Clifton, M G Ziegler, R G Grossman

    Neurosurgery
    |January 1, 1981
    PubMed
    Summary

    Plasma norepinephrine levels correlate with head injury severity. Elevated norepinephrine in severe head injury may indicate sympathetic hyperactivity, impacting metabolism and cardiovascular function.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Relationships and redundancies of selected hemodynamic and structural parameters for characterizing virtual treatment of cerebral aneurysms with flow diverter devices.

    Journal of biomechanics·2015
    Same author

    Globus pallidus internus neuronal activity: a comparative study of linear and non-linear features in patients with dystonia or Parkinson's disease.

    Journal of neural transmission (Vienna, Austria : 1996)·2015
    Same author

    Quantitative comparison of hemodynamic parameters from steady and transient CFD simulations in cerebral aneurysms with focus on the aneurysm ostium.

    Journal of neurointerventional surgery·2014
    Same author

    Effects on blood pressure and autonomic nervous system function of a 12-week exercise or exercise plus DASH-diet intervention in individuals with elevated blood pressure.

    Acta physiologica (Oxford, England)·2011
    Same author

    Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat.

    Human molecular genetics·2010
    Same author

    Predictors of individual visual memory decline after unilateral anterior temporal lobe resection.

    Neurology·2009

    Area of Science:

    • Neuroscience
    • Trauma Medicine
    • Biochemistry

    Background:

    • Head injury can trigger significant physiological responses.
    • Sympathetic nervous system activity is implicated in trauma outcomes.

    Purpose of the Study:

    • To investigate plasma norepinephrine (NE) and dopamine beta-hydroxylase (DBH) levels in head-injured patients.
    • To correlate these levels with injury severity and physiological parameters.

    Main Methods:

    • Measured plasma NE and DBH in 48 head-injured patients within 7 days of injury.
    • Recorded blood pressure, pulse, temperature, and Glasgow Coma Scale (GCS) scores.
    • Analyzed relationships between catecholamine levels and clinical data.

    Main Results:

    Related Experiment Videos

    • NE levels were elevated in multiple trauma patients, irrespective of GCS.
    • In head injury alone, NE levels were proportional to GCS, with coma patients showing up to 7-fold increases.
    • Elevated NE correlated with increased blood pressure, pulse, and temperature.

    Conclusions:

    • Plasma NE levels serve as a potential biomarker for head injury severity.
    • Sympathetic hyperactivity, indicated by elevated NE, may contribute to adverse outcomes like hypermetabolism and cardiovascular issues in severe head injury.
    • Further research is warranted on the direct effects of catecholamines on the injured central nervous system.