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Codon catalog usage is a genome strategy modulated for gene expressivity

R Grantham, C Gautier, M Gouy

    Nucleic Acids Research
    |January 10, 1981
    PubMed
    Summary
    This summary is machine-generated.

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    This study updates a nucleic acid sequence bank with new genes and analyzes codon frequencies, supporting the genome hypothesis and proposing internal regulation of mRNA expression in bacteria.

    Area of Science:

    • Bioinformatics
    • Molecular Biology
    • Genomics

    Background:

    • The nucleic acid sequence bank has been updated with new gene and mRNA sequences.
    • Previous analyses of codon usage have provided insights into genomic properties.

    Purpose of the Study:

    • To update and analyze the contents of a nucleic acid sequence bank.
    • To investigate codon usage patterns and their relationship to genome composition.
    • To propose a model for internal regulation of mRNA expression in bacteria.

    Main Methods:

    • Updating a nucleic acid sequence bank with new mRNA and gene sequences.
    • Calculating codon frequencies for newly added genes and existing genome types.
    • Performing correspondence analyses on codon usage data.

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  • Analyzing third base choices in bacterial codons.

    • Main Results:

    • The nucleic acid sequence bank now includes 161 mRNAs and 43 new genes.
    • Codon frequencies are provided for all added genes and genome types.
    • Correspondence analyses support the genome hypothesis regarding codon usage.
    • A model for internal mRNA expression regulation based on codon choice is proposed for bacteria.

    Conclusions:

    • The updated sequence bank provides a valuable resource for genomic studies.
    • Codon usage patterns are strongly influenced by genome composition.
    • Bacterial mRNA expression may be internally regulated through specific codon choices.