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Treatment of sinusitis and otitis media with pivampicillin
Abstract:
The efficacy and tolerance of two different dosage regimens of pivampicillin was compared in 155 patients with acute sinusitis and in 56 patients with otitis media. Patients received a 10-day course of either 500 mg pivampicillin twice daily, or 350 mg pivampicillin 3-times a day. Out of the 155 patients with sinusitis, 68 patients received pivampicillin at the time of diagnosis, whilst in a further 87 patients treatment was given, on average, 7 days after the diagnosis was made. Approximately 78% of the patients had Proetz suction and 17% used nasal drops or spray. Among 77 patients given the 500 mg dose, 88% were cured, 8% improved and only 4% failed to respond. Ninety-one per cent of 70 evaluated patients receiving the 350 mg dose were cured and 9% were improved. Paracentesis was performed on 43 of the 56 patients with otitis media and spontaneous perforation occurred in 7 patients. Eight patients received supplementary treatment with ear drops. Ninety-one per cent of 32 evaluated patients on the 500 mg dose were cured and 9% improved. The corresponding response rate in 20 evaluated patients given the 350 mg tablets was 80% cured, 15% improved and 5% of patients failed to respond. There was no difference in the frequency of side-effects between the two regimens. Approximately 4% of the patients had gastro-intestinal side-effects or skin rashes and in only 6 patients did these necessitate withdrawal of therapy. The twice daily regimen is recommended because of increased patient compliance.
Insights
This study compared two pivampicillin dosages for acute sinusitis and otitis media. The twice-daily 500 mg regimen is recommended for better patient compliance and similar efficacy to the three-times-daily 350 mg dose.
Area of Science:
- Pharmacology
- Infectious Diseases
- Otolaryngology
Background:
- Pivampicillin is an antibiotic used to treat bacterial infections.
- Acute sinusitis and otitis media are common infections affecting the upper respiratory tract and middle ear, respectively.
- Optimizing antibiotic dosage regimens is crucial for treatment efficacy and patient adherence.
Purpose of the Study:
- To compare the efficacy and tolerance of two different pivampicillin dosage regimens.
- To evaluate the effectiveness of pivampicillin in patients with acute sinusitis and otitis media.
- To determine the optimal dosing schedule for pivampicillin based on patient compliance and treatment outcomes.
Main Methods:
- A comparative study involving 155 patients with acute sinusitis and 56 patients with otitis media.
- Patients received a 10-day course of either 500 mg pivampicillin twice daily or 350 mg pivampicillin three times daily.
- Treatment outcomes were assessed based on cure rates, improvement, and treatment failure, with side-effects also monitored.
Main Results:
- For acute sinusitis, cure rates were 88% for the 500 mg twice-daily regimen and 91% for the 350 mg three-times-daily regimen.
- For otitis media, cure rates were 91% for the 500 mg twice-daily regimen and 80% for the 350 mg three-times-daily regimen.
- No significant difference in side-effect frequency was observed between the two regimens, with most side-effects being mild gastro-intestinal issues or skin rashes.
Conclusions:
- Both pivampicillin dosage regimens demonstrated high efficacy in treating acute sinusitis and otitis media.
- The twice-daily 500 mg regimen is recommended due to potentially higher patient compliance compared to the three-times-daily 350 mg regimen.
- Pivampicillin is a well-tolerated antibiotic for these common infections, with minimal adverse events necessitating treatment withdrawal.