Effects of caffeine administration on food and water consumption under various experimental conditions

The effects of caffeine on food and water intake was assessed in rats maintained under several experimental conditions. In Experiment 1, caffeine, 3.125, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/kg was injected into 23 hr food deprived, 23 hr water deprived or ad lib animals. In Experiment 2, animals were adapted to a 21 hr food deprivation schedule and administered the same doses of caffeine as were used in Experiment 1. Results indicate that caffeine both enhances and decreases food and water intake and that the effects observed depend on the experimental circumstances.