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Updated: Aug 9, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice
Published on: August 25, 2012
Computer controlled hyperthermia unit for cancer therapy
Abstract:
Hyperthermia is the artificial elevation of tissue temperature above 41 degrees C with therapeutic intent. Most of the currently used hyperthermia units lack feedback temperature control mechanisms, and, therefore, are not optimal for clinical trials. To solve this problem, we have developed a control system based on a microcomputer. The computer measures the tumor and normal tissue temperature using fine thermocouple sensors and regulates the output of the microwave generator to achieve and maintain the prescribed tumor temperature under specified conditions. Safety procedures are incorporated to avoid heating the tumor or normal tissue beyond predetermined limits.
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