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Drug discrimination learning in lead-exposed rats

H Zenick, M Goldsmith

Science (New York, N.Y.)

|May 1, 1981

Summary

Lead exposure in dams reduced offspring sensitivity to d-amphetamine. This effect persisted regardless of continued lead exposure after weaning, impacting drug-discrimination learning.

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Area of Science:

Neuroscience
Toxicology
Pharmacology

Background:

Lead exposure during development is a significant public health concern.
Understanding the long-term neurological effects of developmental lead exposure is crucial.

Purpose of the Study:

To investigate the impact of developmental lead exposure on the behavioral effects of d-amphetamine.
To determine if continued lead exposure post-weaning alters sensitivity to amphetamine's stimulus properties.

Main Methods:

Pregnant dams were administered lead acetate throughout lactation.
Offspring were tested using a drug-discrimination learning paradigm to determine d-amphetamine thresholds.
Exposure groups included offspring exposed during lactation only and those exposed throughout lactation and post-weaning.

Main Results:

All offspring exposed to lead acetate showed reduced sensitivity to the stimulus properties of d-amphetamine.
This decreased sensitivity was observed irrespective of whether lead exposure continued after weaning.
Developmental lead exposure significantly altered the dose-response relationship for d-amphetamine.

Conclusions:

Developmental exposure to lead acetate induces lasting changes in behavioral sensitivity to amphetamine.
The observed neurobehavioral effects are established early in development and are not necessarily exacerbated by continued exposure.
Lead's disruption of neurochemical systems involved in drug discrimination may underlie these findings.

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