Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gallbladder function in experimental cholecystitis

J Svanvik, E Thornell, L Zettergren

    Surgery
    |April 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Donor Monoclonal Gammopathy May Cause Lymphoproliferative Disorders in Solid Organ Transplant Recipients.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
    Same author

    Commentary: the rising tide of cholecystectomy for biliary dyskinesia.

    Alimentary pharmacology & therapeutics·2013
    Same author

    Gene expression profile of colon cancer cell lines treated with SN-38.

    Chemotherapy·2010
    Same author

    Segmental ischemia of the liver - microdialysis in a novel porcine model.

    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes·2009
    Same author

    Selective iNOS inhibition enhances spontaneous gallbladder motility in the Australian possum.

    Neurogastroenterology and motility·2007
    Same author

    Serum amino acid profile in patients with acute pancreatitis.

    Amino acids·2007
    Same journal

    Outcomes following endovascular aortic aneurysm repair in nonagenarian patients.

    Surgery·2026
    Same journal

    Fistulotomy with primary sphincteroplasty for complex anal fistulas: Should we be concerned about incontinence?

    Surgery·2026
    Same journal

    No need for mesh in the repair of hiatal hernias: Autologous tissue hiatoplasty techniques for the repair of the complex diaphragmatic defect.

    Surgery·2026
    Same journal

    Incretin-based therapies and altered myocardial metabolism in a swine model of ischemic heart disease in the setting of metabolic syndrome.

    Surgery·2026
    Same journal

    Colonoscopy utilization and persistent disparities in early onset colorectal cancer: A multistate, multi-institution nested case-control study.

    Surgery·2026
    Same journal

    From blades to heels: Lessons in performance from the ice to the practice of surgery.

    Surgery·2026
    See all related articles

    Experimental cholecystitis in cats showed that gallbladder inflammation and bile flow are linked to cystic duct obstruction. Prostaglandins may drive these inflammatory responses, suggesting therapeutic targets.

    Area of Science:

    • Gastroenterology
    • Pathophysiology
    • Animal Models

    Background:

    • Cholecystitis, or gallbladder inflammation, is a common clinical condition.
    • The role of prostaglandins in gallbladder function and inflammation is not fully understood.
    • Animal models are crucial for studying complex physiological processes.

    Purpose of the Study:

    • To investigate the functional and morphological changes in experimental cholecystitis.
    • To explore the role of prostaglandins in gallbladder fluid secretion and hepatic bile flow.
    • To correlate gallbladder function with observed morphologic changes.

    Main Methods:

    • Inducing experimental cholecystitis in cats using human gallstones.
    • Utilizing a perfusion technique to assess gallbladder function and hepatic bile flow.

    Related Experiment Videos

  • Correlating functional assessments with histological examination of gallbladder tissue.

    • Main Results:

    • Cystic duct obstruction led to pronounced gallbladder inflammation and fluid secretion.
    • Patent cystic ducts showed less inflammation and maintained gallbladder concentrating activity.
    • Both obstructed and patent groups exhibited increased hepatic bile outflow, reversed by indomethacin.

    Conclusions:

    • Prostaglandins appear to mediate gallbladder fluid secretion and increased hepatic bile flow in cholecystitis.
    • Indomethacin (prostaglandin synthetase inhibitor) reversed these effects, suggesting a therapeutic mechanism.
    • Findings provide insights into clinical cholecystitis and potential prostaglandin-targeted treatments.