DNA radiosensitivity in carcinoma of the human cervix

The radiosensitivity of DNA in human cervix carcinoma was examined by using alkaline sucrose gradient centrifugation to measure radiation-induced single-strand breaks. The DNA strand-break efficiencies observed in DNA of 18 specimens fell into two distinct groups, radiosensitive and radioresistant. The difference in DNA radiosensitivity may be correlated with the pathological classifications of the carcinomas.