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Related Experiment Videos

Indole toxicity in cattle

A C Hammond, J R Carlson, R G Breeze

    The Veterinary Record
    |October 11, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Oral administration of indole in cows led to decreased packed cell volume and increased plasma hemoglobin, causing hemoglobinuric nephrosis. Indole did not induce acute bovine pulmonary emphysema (ABPE) in this study.

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    Area of Science:

    • Veterinary Medicine
    • Toxicology
    • Animal Science

    Background:

    • Indole and 3-methylindole (3MI) are ruminal L-tryptophan metabolites with similar properties.
    • 3-Methylindole is known to cause acute bovine pulmonary emphysema (ABPE).

    Purpose of the Study:

    • To determine the effects of orally administered indole in cows.
    • To investigate if indole induces ABPE or other toxic effects.

    Main Methods:

    • Four Holstein cows received escalating oral doses of indole (0.05, 0.1, 0.2 g/kg) at two-week intervals.
    • Plasma indole concentrations, packed cell volume, and plasma hemoglobin were monitored.
    • Animals were necropsied one week after the final dose.

    Main Results:

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    • Plasma indole peaked at 3 hours post-administration, with detectable levels persisting for 25 hours.
    • Significant decreases in packed cell volume and increases in plasma hemoglobin were observed at higher doses.
    • Clinical signs included diarrhea, hemolysis, hemoglobinuria, and microscopic lesions of hemoglobinuric nephrosis in all cows.

    Conclusions:

    • Oral indole administration in cows causes systemic toxicity, including renal damage, but does not induce ABPE.
    • Indole's toxic effects differ from those of 3MI, despite their structural similarities.