Effect of endosulfan of bioelectrical activity of brain in rats

Bioelectrical activity of rat brain was studied after administration of endosulfan (5 mg/kg, ip) for 10 days. The pesticide produced rhythmic bursts of spikes and waves of seizure pattern that started 25-30 minutes after dosing and persisted for 60-minutes. The clonic convulsions were more marked over the head region and were mainly localized in the upper extremities. Histopathologic examination of the liver showed congestion of the central veins and its adjacent sinusoids. Concentration of the compound in brain parallelled the electrical activity.