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[Sedative-hypnotic compounds in the exhalation of hops, II]
Zeitschrift Fur Naturforschung. Section C, Biosciences
|November 1, 1980
Summary
Hops contain a sleep-promoting compound, 2-methyl-3-butene-2-ol. This alcohol, when administered to mice, induced prolonged narcosis, suggesting its role in the sedative effects of hops.
Area of Science:
- Pharmacology
- Phytochemistry
- Sleep Science
Background:
- Hops are traditionally associated with promoting sleep.
- Previous attempts to identify the specific sleep-inducing compound in hops have been unsuccessful.
- The volatile fraction of hops is suspected to contain soporific agents.
Purpose of the Study:
- To identify the chemical compound responsible for the sedative effects of hops.
- To investigate the pharmacological activity of identified compounds from hops.
Main Methods:
- Preliminary pharmacological testing was conducted.
- Analysis of the volatile fraction of hops was performed.
- Administration of 2-methyl-3-butene-2-ol to mice via intraperitoneal injection.
Main Results:
- The compound 2-methyl-3-butene-2-ol was identified in the volatile fraction of hops.
- Administration of 2-methyl-3-butene-2-ol (0.80 g/kg) to mice resulted in approximately 8 hours of narcosis.
- No abnormal behavior was observed in mice post-administration.
- 2-methyl-3-butene-2-ol is enriched in the more volatile fractions of hops due to its water solubility affecting concentration in steam-distilled essential oils.
Conclusions:
- 2-methyl-3-butene-2-ol is likely the principal soporific compound in hops.
- The identified alcohol exhibits significant sedative properties in preliminary animal studies.
- Further research is warranted to explore the therapeutic potential of 2-methyl-3-butene-2-ol for sleep disorders.