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Updated: Aug 12, 2026

The Tail Suspension Test
Published on: January 28, 2012
[Effect of discontinuation of long-term preventive lithium therapy]
Abstract:
The development of manic-depressive psychoses (15 cases) and attack-like schizophrenia (20 cases) was studied, following a withdrawal of a durable and successful prophylactic intake of lithium preparations. A comparison with a control group selected according to the double method, not suspending the administration of lithium salts, demonstrated a statistically significant increase of phases-attacks, their aggravation as well as an increased amount of hospitalizations due to lithium withdrawal. The conclusion is made that there is a necessity for durable and continuous lithium prophylaxis even after obtaining complete remissions.
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